During the last years our research interest was focused on organoselenium compounds with organic groups of type 2r2nch2c6h4 r me, et, pri. The chemistry chapters are organized according to the different reactivities of various selenium compounds and reagents, with each chapter dealing with a special reaction type. Brings to readers the state of the art of organoselenium compounds as. Selenium is naturally present in soils but it is also produced by pollution from human activities into the environment. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The basic molecular mechanisms involved in organoselenium mediated cytotoxicity are still not completely understood. Organoselenium shows incredible promise in medicine, particularly cancer therapy.
Organoselenium compounds in biology and medicine pdf libribook. Organosulfur compound, a subclass of organic substances that contain sulfur and that are known for their varied occurrence and unusual properties. The rate of deiodination was found to be significantly higher than that of the debromination for both. Reich contribution from the department of chemistry, university of wisconsin. Organoselenium compounds as mimics of selenoproteins and. Electrophilic and nucleophilic selenium selenium compounds in radical reactions seleniumstabilized carbanions. The ability of ebselen to mimic the reaction catalyzed by gpx has been viewed as the most important molecular mechanism of action of this class of compound. Organoselenium compounds an overview sciencedirect topics. Organoselenium compounds in biology and medicine pdf organoselenium shows incredible promise in medicine, particularly cancer therapy. Organoselenium chemistry is the corresponding science exploring their properties and reactivity. Free radical induced selenoxide formation in isomeric. Indirect detection of selenium77 in nuclear magnetic. Chemistry of biologically important synthetic organoselenium.
This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and. Antioxidantprooxidant properties of a new organoselenium. New frontiers in organoselenium compounds springerlink. Pdf converter is a online webbased document to pdf converter software. Organoselenium compounds modulate extracellular redox by. An investigation of the influence of the compound on oxidative stress and antioxidant enzyme system. Aibn is a common initiator for thermal processes, typically used in amounts of 510 mol%. New frontiers in organoselenium compounds eder joao. The arylselenium compounds benzeneselenol phseh, dibenzyl diselenide dbdse, diphenyl diselenide dpdse, and ebselen were capable of inducing extracellular cysteine accumulation via a cystine and glucosedependent process. Organoselenium compounds as phytochemicals from the natural kingdom. Also includes a table with 77se nmr shifts to aid in practical problems. This pdf is available for free download from a site hosted by medknow publications. Organosulfur compounds occur in the bodies of all living creatures in the form of certain essential amino acids, enzymes, coenzymes, vitamins, and hormones. Apart from usage of selenium compounds in diseases prevention by selenium supplementation, developing of synthetic organoselenium compounds as well as their metal complexes is subject of research.
Xray crystallographic files cif of crystal data collection and refinement parameters, atomic coordinates, bond lengths and angles. The following 22 files are in this category, out of 22 total. Between synthesis and biochemistry an excellent reference about selenium chemistry for researchers and graduate students in the field of selenium chemistry. The chemistry of organoselenium compounds has undergone rapid growth during the past three decades due to their increasing applications. Chemistry of biologically important synthetic organoselenium compounds. Chemoenzymatic approaches to obtain chiralcentered. Derived organoselenium compounds with glutathione peroxidase. Organoselenium compounds are chemical compounds containing carbontoselenium. Organoselenium compounds as phytochemicals from the natural.
Reich contribution from the department of chemistry, university of wisconsin, madison, wisconsin 53706. Pdf biological importance of organoselenium compounds. The book organoselenium chemistry between synthesis and biochemistry edited by prof claudio santi is a useful tool for chemists and biochemists who are interested in delving in the green side of the moon, as prof santi has been calling the new, green aspects of organoselenium. Organoselenium compounds are powerful antioxidants with potent antiinflammatory and analgesic effects as assessed by several animal studies. In addition to work at wisconsin, research groups headed by.
Organoselenium compounds are chemical compounds containing carbonto selenium. Recent advances of structural chemistry of organoselenium and organotellurium compounds. Antifungal organoselenium compound loaded nanoemulsions. A number of eminent scientists from different research groups were involved in the preparation of the chapters of the book, making organoselenium chemistry.
Organoselenium compounds in cancer chemoprevention. Gyor, hungary, 46th of may 2018 oral presentation in english. Wirth, in comprehensive organometallic chemistry iii, 2007. Antifungal organoselenium compound loaded nanoemulsions stabilized by bifunctional cationic surfactants magdalena pietkaottlika, agnieszka lewinskab, anna jarominc, anna krasowskad, kazimiera a. Achibat h, alomari na, messina f, sancineto l, khouili m, santi c. Pdf synthetic organoselenium compounds in medicinal domain. The results obtained can be divided in three main subchapters according to the approached class of compounds.
Organoselenium compounds in biology and medicine rsc. Functional group manipulation usin organoselenium reagents. A brief overview of the chemistry of genus allium plants, particularly garlic allium sativum and onion allium cepa, is followed by a discussion of the metabolism of allium compounds and their anticarcinogenic, antibiotic, anticoagulant, antiatherogenic, antihyperlipidaemic, antihypertensive, immune system, heptapic system, bird repellent. Other readers will always be interested in your opinion of the books youve read. Synthesis and antibacterial activity of novel organoselenium. Simple low molecular weight selenium compounds as well as more complicated organoselenium phosphites with a high structural diversity were involved in the study. Waterdependent synthesis of biologically active diaryl. Organoselenium compound an overview sciencedirect topics. Complete listing of observed and calculated raman bands for 15 and 21. Divided into three sections, the first section describes synthetic advances in bioactive selenium compounds, revealing. Small molecules of organoselenium and organotellurium compounds have emerged as excellent candidates to act as gpx mimics, due to their wellknown ability to undergo twoelectron redox cycle between chalcogen ii and iv species. Selenium influences a number of endocrine processes. In addition to work at wisconsin, research groups headed by sharpless, seebach, grieco, krief, nicolaou, and others. Therefore, the design and synthesis of organoselenium compounds with biological activity currently constitute engaging.
Due to the fact that organoselenium compounds show better antioxidative effect than classical selenium made a new era of preparing novel synthetic selenium compounds selamoglu talas 2015. In contrast to popular opinion, organoselenium compounds are not artificial or alien to biology. Antitumor activity of organoselenium compounds against specific tumor types with significant mortality in hungary. All three compounds induced rapid and sustained expression of the cell cycle inhibitor p21 at both mrna and protein levels.
Organoselenium compound article about organoselenium. Whether youve loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them. Through the more than 420 pages of the book, its possible to find the more recent advances in the synthesis and application of selenium compounds in chemistry, biochemistry and food chemistry, as well as modern nmr techniques to characterization of organoselenium compounds. Aug 14, 2014 one of the vitamin b6 vitamers, pyridoxine, was modified to incorporate selenium in various oxidation states in place of the methyl group in position 2. Synthesis, characterization, structures and antioxidant activity of nicotinoyl based organoselenium compounds. Selenium belongs with oxygen and sulfur to the group 16 elements or chalcogens, and similarities in chemistry are to be expected selenium can exist with oxidation state. In human colon cancer cells, am, msp and kmsb decreased hdac activities, and induced rapid histone hyperacetylation in a dose. Diorgano diseleniumi compounds compounds from this class have attracted considerable interest in the last decade.
This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications. Stanford libraries official online search tool for books, media, journals, databases, government documents and more. View the article pdf and any associated supplements and figures for a period of 48 hours. Pages in category organoselenium compounds the following 20 pages are in this category, out of 20 total. The key to this success is that a fair number of selenium based reagents and reactions have been. Organotellurium and organoselenium compounds attenuate mn. During the last fifteen years organoselenium chemistry underwent a spectacular mutation. Review of organoselenium chemistry between synthesis and. Contributions to the chemistry of organoselenium compounds. The connection between organoselenium compounds and green chemistry, despite having only recently emerged, is one of the subjects of this book. Catalytic application of selenium and tellurium compounds.
Organoselenium compounds represent a new class of reagents and catalysts in modern chemistry, green chemistry, and biological response. Synthesis and antibacterial activity of novel organoselenium compounds. Find out information about organoselenium chemistry. The scope and limitation of the transformation ketones to enones by selenenylation followed selenoxide elimi. Organoselenium compounds in biology and medicine rsc publishing. Antimicrobial activity of organoselenium compounds bentham.
Organoselenium chemistry article about organoselenium. Stereochemical challenges posed by these intricate and densely functionalized cyclopentanes will be discussed. In the pursuit of synthons for oroidin dimers such as palauamine, the stereocontrolled synthesis of complex c 5 rings has seen a renaissance in recent years. The first chapter highlights the use of secontaining molecules as reagents and catalysts in new green protocols to. In fact, to be activated the organoselenium compounds react with thiols and, consequently, consume thiols. What links here related changes upload file special pages permanent link page. Wilka a department of organic and pharmaceutical technology, faculty of chemistry, wroclaw. Foxit software is the reliable source for fast, affordable, and secure pdf solutions. Popa centre of supramolecular organic and organometallic chemistry, department of chemistry, faculty of chemistry and chemical engineering, babes. Studies on the properties of organoseleniumiv fluorides. Selenium belongs with oxygen and sulfur to the group 16 elements or chalcogens, and similarities in chemistry are to be expected. Evaluation of organoselenium based compounds as co. Organoselenium compounds in biology and medicine synthesis. The compounds obtained for this purpose can be classified into some main categories like cyclic selenyl amides, diselenides, linear or cyclic selenides, vinyl selenides and.
Pdf organoselenium chemistry has emerged as an outstanding area in recent years due to its essential role in synthesis of a large number of. Conversion of ketones to enones by selenoxide syn elimination hans j. Organoselenium compounds are chemical compounds containing carbontoselenium chemical bonds. Developments in synthetic application of seleniumiv oxide and. Anoxidativeapproach wasapplied to racemic organoselenium compounds in order to perform their kinetic resolution in enzymemediated reactions fig. Between synthesis and biochemistry the use of organoselenium reagents as catalysts is a common thread that runs through the chapters of this book, introducing important aspects of the modern organoselenium chemistry. Organoselenium compounds, an overview on the biological. Organoselenium compounds as phytochemicals from the. Daiana silva avilaa, alexandre benedetto, catherine au, flavia manarin, keith erikson. Nutritional modulators of pain in the aging population, 2017. Synthesis, structure, tiniv complexes and antiproliferative activity roxana a.
Studies on the properties of organoseleniumiv fluorides and. Organoselenium compounds containing pyrazole or phenylthiazole groups. Glass department of chemistry, university of arizona, tucson, arizona 85721, usa. Selenium, a nonmetallic element, has structural and enzymatic roles. Pdf selenium, a nonmetallic element, has structural and enzymatic roles. Such compounds were conveniently accessed by treatment of bis. Selenium can be introduced as an electrophile, as a nucleophile, or as a radical.
The effect of selenium compounds on extracellular redox modulating capacity was studied in murine macrophage raw 264. Both nucleophilic and electrophilic reagents are readily available for the introduction of selenium. In recent years, a particular interest has been given to organoselenium compounds as antioxidants, regulating free radical reactions in the organism, and mimicking glutathione peroxidase gpx activity 14. In the last few years, a number of novel synthetic organoselenium compounds have been synthesized for their use as antioxidants in medicinal chemistry. Media in category organoselenium compounds the following 22 files are in this category, out of 22 total. Convert and create pdf from various types of files like word doc, excel xls, powerpoint ppt. The term gpxlike or thiol peroxidaselike reaction was previously coined in the field and it is now accepted as the most important chemical attribute of organoselenium compounds. Oct 20, 2016 herein we report the synthesis of new organoselenium compounds and their evaluation as co. Organotellurium and organoselenium compounds attenuate mn induced toxicity in c. This list may not reflect recent changes learn more. The results thereby suggest that formation of selenoxides improves the antioxidant activity of organoselenium compounds and should be considered as an important step in the design of new selenium based antioxidants. An organic compound that contains both selenium and carbon, and frequently other elements, such as the halogens, oxygen, sulfur, or nitrogen explanation of organoselenium chemistry.
Xray crystallographic files cif of crystal data collection and refinement parameters, atomic coordinates, bond lengths and angles, and anisotropic displacement parameters for compounds sedtc 2 c 6 h 6, 5, 5a, 5b, and 7a. Organoselenium compounds are known to possess antioxidant, anticancer and antibacterial. Synthesis, structure, tiniv complexes and antiproliferative activity. Page 6 authors scenario, we recently reported new synthetic procedures for the synthesis of seleniumcontaining functionalized small molecules under mild conditions. Antimicrobial activity of organoselenium compounds. Divided into three sections, the first section describes synthetic advances in bioactive selenium compounds, revealing how. The selenoxides undergo reduction by thiols, thereby regenerating back to the parent compound. Organoselenium compounds in biology and medicine pdf. Selenium compounds as ligands and catalysts springerlink. Wilka a department of organic and pharmaceutical technology, faculty of chemistry, wroclaw university of science and technology, wybrzeze wyspianskiego 29, 50370 wroclaw. Redox cycling of methylselenide and other selenides rse. New organoselenium methodology dennis liotta department of chemistry, emory university, atlanta, georgia 30322 received january 15, 1982 revised manuscript received july 22, 1983 although the field of organoselenium chemistry dates back to the 19th century, it did not become a part of the mainstream of organic chemistry until the early 1970s.
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